Title : Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts.

Pub. Date : 2018 Apr

PMID : 29275510






1 Functional Relationships(s)
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1 Our data suggest that 100 muM BPA increased CYP1B1 and HSD17B14 gene and protein expression and release of endogenous estradiol, which was associated with increased ROS production and DNA double-strand breaks, upregulation of genes and/or proteins in steroid synthesis and metabolism, and activation of Nrf2-regulated stress response pathways. Steroids cytochrome P450 family 1 subfamily B member 1 Homo sapiens