Title : Inhibition of activated factor X by rivaroxaban attenuates neointima formation after wire-mediated vascular injury.

Pub. Date : 2018 Feb 5

PMID : 29269019






2 Functional Relationships(s)
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1 Quantitative RT-PCR analyses demonstrated that rivaroxaban reduced the expression of inflammatory molecules (e.g., IL-1beta and TNF-alpha) in injured arteries at seven days after surgery (P<0.05, respectively). Rivaroxaban interleukin 1 beta Mus musculus
2 In vitro experiments using mouse peritoneal macrophages demonstrated that FXa increased the expression of inflammatory molecules (e.g., IL-1beta and TNF-alpha), which was blocked in the presence of rivaroxaban (P<0.05). Rivaroxaban interleukin 1 beta Mus musculus