Title : The cysteinyl leukotriene receptor 1 (CysLT1R) antagonist montelukast suppresses matrix metalloproteinase-13 expression induced by lipopolysaccharide.

Pub. Date : 2018 Feb

PMID : 29268191






1 Functional Relationships(s)
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1 Mechanistically, we found that montelukast suppressed LPS-induced nuclear translocation of NF-kappaB p65 as well as NF-kappaB transcriptional activity by inhibiting the phosphorylation and degradation of IkappaBalpha. montelukast nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus