Title : Variations in plasma concentrations of tamoxifen metabolites and the effects of genetic polymorphisms on tamoxifen metabolism in Korean patients with breast cancer.

Pub. Date : 2017 Nov 21

PMID : 29245979






1 Functional Relationships(s)
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1 CYP2D6 AS was the only variable that showed associations with both metabolite concentration and ratio: endoxifen (P < 0.001), NDM (P < 0.001), endoxifen/NDM (P < 0.001), NDM/tamoxifen (P < 0.001), and 4-OH tamoxifen/tamoxifen (P = 0.005). hydroxytamoxifen cytochrome P450 family 2 subfamily D member 6 Homo sapiens