Pub. Date : 2017 Dec 14
PMID : 29242562
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line. | Reactive Oxygen Species | caspase 8 | Homo sapiens |
| 2 | Here we show that the NHL-repeat-containing protein 2 (NHLRC2) thioredoxin-like domain protein is cleaved by caspase-8 in ROS-induced apoptosis in the HCT116 human colon cancer cell line. | Reactive Oxygen Species | caspase 8 | Homo sapiens |
| 3 | Furthermore, siRNA-mediated knockdown of caspase-8 blocked the ROS-induced decrease in NHLRC2 protein levels. | Reactive Oxygen Species | caspase 8 | Homo sapiens |
| 4 | These results suggest that excess ROS production causes a caspase-8-mediated decrease in NHLRC2 protein levels, leading to apoptotic cell death in colon cancer cells, and indicate an important role of NHLRC2 in the regulation of ROS-induced apoptosis. | Reactive Oxygen Species | caspase 8 | Homo sapiens |
| 5 | These results suggest that excess ROS production causes a caspase-8-mediated decrease in NHLRC2 protein levels, leading to apoptotic cell death in colon cancer cells, and indicate an important role of NHLRC2 in the regulation of ROS-induced apoptosis. | Reactive Oxygen Species | caspase 8 | Homo sapiens |