Title : Ruthenium(ii) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines.

Pub. Date : 2018 Jan 2

PMID : 29235601






2 Functional Relationships(s)
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1 Molecular docking studies with COX-2 reveal that complexes 1 and 2 having naproxen and diclofenac ligands exhibit stronger interactions with COX-2 than their respective free NSAIDs and these results are in good agreement with their relative experimentally observed COX inhibition as well as anti-proliferative activities. Diclofenac mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Molecular docking studies with COX-2 reveal that complexes 1 and 2 having naproxen and diclofenac ligands exhibit stronger interactions with COX-2 than their respective free NSAIDs and these results are in good agreement with their relative experimentally observed COX inhibition as well as anti-proliferative activities. Diclofenac mitochondrially encoded cytochrome c oxidase II Homo sapiens