Pub. Date : 2017
PMID : 29234413
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway. | rhodioloside | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | In this study, we found that Sal significantly prevented MPP+-induced decrease of mRNA and protein expression of Nrf2, GCLc, SOD1, and SOD2 in SH-SY5Y cells. | rhodioloside | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Moreover, silencing of Nrf2 significantly inhibited Sal-induced increase in mRNA and protein expression of GCLc, SOD1, and SOD2. | rhodioloside | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | Silencing of Nrf2 significantly suppressed the decrease of apoptosis induced by Sal in MPP+-treated SH-SY5Y cells. | rhodioloside | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | Moreover, silencing of DJ-1 significantly inhibited Sal-induced increase in mRNA and protein expression of Nrf2, GCLc, SOD1, and SOD2 in MPP+-treated SH-SY5Y cells. | rhodioloside | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 6 | These results indicated that DJ-1 was an upstream regulator of Nrf2 in the neuroprotective effects of Sal. | rhodioloside | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 7 | In conclusion, Sal prevented MPP+-induced neurotoxicity through upregulation of DJ-1-Nrf2-antioxidant pathway. | rhodioloside | NFE2 like bZIP transcription factor 2 | Homo sapiens |