Title : Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner.

Pub. Date : 2017 Dec

PMID : 29233468






1 Functional Relationships(s)
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1 By using wound healing and transwell-based invasion models, we demonstrated that pretreatment of butyrate significantly inhibited motility of HCT116, HT29, LOVO and HCT8 cells, this activity was further attributed to deactivation of Akt1 and ERK1/2. Butyrates mitogen-activated protein kinase 3 Homo sapiens