Pub. Date : 2017 Dec 12
PMID : 29233105
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway. | rhodioloside | unc-51 like autophagy activating kinase 1 | Homo sapiens |
| 2 | P-AMPK (Thr 172) and P-ULK1 (Ser 555) of the AMPK-ULK1 pathway were increased in the hypoxia group and were further increased in the salidroside group. | rhodioloside | unc-51 like autophagy activating kinase 1 | Homo sapiens |
| 3 | P-AMPK (Thr 172) and P-ULK1 (Ser 555) of the AMPK-ULK1 pathway were increased in the hypoxia group and were further increased in the salidroside group. | rhodioloside | unc-51 like autophagy activating kinase 1 | Homo sapiens |
| 4 | Furthermore, P-mTOR (Ser 2448) and P-ULK1 (Ser 757) of the AMPK-mTOR-ULK1 pathway were decreased in the hypoxia group and were further decreased in the salidroside group. | rhodioloside | unc-51 like autophagy activating kinase 1 | Homo sapiens |
| 5 | Furthermore, P-mTOR (Ser 2448) and P-ULK1 (Ser 757) of the AMPK-mTOR-ULK1 pathway were decreased in the hypoxia group and were further decreased in the salidroside group. | rhodioloside | unc-51 like autophagy activating kinase 1 | Homo sapiens |
| 6 | CONCLUSIONS: Salidroside might inhibit hypoxia-induced PASMC proliferation and reverse apoptosis resistance via the upregulation of autophagy through both the AMPKalpha1-ULK1 and AMPKalpha1-mTOR-ULK1 pathways. | rhodioloside | unc-51 like autophagy activating kinase 1 | Homo sapiens |
| 7 | CONCLUSIONS: Salidroside might inhibit hypoxia-induced PASMC proliferation and reverse apoptosis resistance via the upregulation of autophagy through both the AMPKalpha1-ULK1 and AMPKalpha1-mTOR-ULK1 pathways. | rhodioloside | unc-51 like autophagy activating kinase 1 | Homo sapiens |