Title : Low-dose bisphenol A activates the ERK signaling pathway and attenuates steroidogenic gene expression in human placental cells.

Pub. Date : 2018 Feb 1

PMID : 29228121






1 Functional Relationships(s)
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1 In steroid hormone synthesis, two specific enzymes are important: P450scc (CYP11A1) converts cholesterol to pregnenolone and aromatase (CYP19) induces androgen conversion to estrogen.To determine the effects of a low dose of BPA on hormone synthesis in the placenta, we used JEG-3 cells as a model. Pregnenolone cytochrome P450 family 11 subfamily A member 1 Homo sapiens