Title : Differential modulation of Bax/Bcl-2 ratio and onset of caspase-3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375.

Pub. Date : 2017 Nov 10

PMID : 29221182






3 Functional Relationships(s)
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1 Diphyllin methyl ether (GI50 = 3.66 muM) and Justicidin B (GI50 = 1.70 muM) caused an elevation of both early and late apoptosis populations whereas Diphyllin apioside (GI50 = 0.84 muM) and its acetate (GI50= 0.39 muM) enhanced late apoptosis population only (Annexin V-positive/PI-positive). justicidins latexin Homo sapiens
2 Diphyllin methyl ether (GI50 = 3.66 muM) and Justicidin B (GI50 = 1.70 muM) caused an elevation of both early and late apoptosis populations whereas Diphyllin apioside (GI50 = 0.84 muM) and its acetate (GI50= 0.39 muM) enhanced late apoptosis population only (Annexin V-positive/PI-positive). justicidins latexin Homo sapiens
3 Diphyllin methyl ether (GI50 = 3.66 muM) and Justicidin B (GI50 = 1.70 muM) caused an elevation of both early and late apoptosis populations whereas Diphyllin apioside (GI50 = 0.84 muM) and its acetate (GI50= 0.39 muM) enhanced late apoptosis population only (Annexin V-positive/PI-positive). justicidins latexin Homo sapiens