Title : Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-κB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages.

Pub. Date : 2018 Feb

PMID : 29207042






2 Functional Relationships(s)
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1 Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-kappaB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages. Lovastatin thymoma viral proto-oncogene 1 Mus musculus
2 Therefore, the present study demonstrates that lovastatin inhibits the expression of pro-inflammatory mediators, including iNOS and TNF-alpha, through the suppression of HDAC1 expression, PI3K/Akt phosphorylation and NF-kappaB translocation in LPS-stimulated RAW264.7 macrophage cells. Lovastatin thymoma viral proto-oncogene 1 Mus musculus