Title : Tunicamycin-induced ER stress in breast cancer cells neither expresses GRP78 on the surface nor secretes it into the media.

Pub. Date : 2018 Feb 1

PMID : 29206917






3 Functional Relationships(s)
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1 We have evaluated the effect of tunicamycin on cellular localization of GRP78 in metastatic human breast cancer cells MDA-MB-231 (ER-/PR-/HER2-). Tunicamycin heat shock protein family A (Hsp70) member 5 Homo sapiens
2 GRP78 expression (protein and mRNA) was higher in tunicamycin (1.0 mug/mL) treated MCF-7 and MDA-MB-231 cells. Tunicamycin heat shock protein family A (Hsp70) member 5 Homo sapiens
3 The conclusion, GRP78 is expressed neither on the outer-leaflet of the (ER-/PR-/HER2-) human breast cancer cells nor it is secreted into the culture media during tunicamycin-induced ER stress. Tunicamycin heat shock protein family A (Hsp70) member 5 Homo sapiens