Title : Design, synthesis and structure-activity relationship of a focused library of β-phenylalanine derivatives as novel eEF2K inhibitors with apoptosis-inducing mechanisms in breast cancer.

Pub. Date : 2018 Jan 1

PMID : 29202403






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1 Design, synthesis and structure-activity relationship of a focused library of beta-phenylalanine derivatives as novel eEF2K inhibitors with apoptosis-inducing mechanisms in breast cancer. beta-phenylalanine eukaryotic elongation factor 2 kinase Homo sapiens
2 In this study, we discovered a beta-phenylalanine scaffold by virtual high-throughput screening, as well as designed and synthesized 46 derivatives with assessment of inhibition activity against eEF2K and cytotoxicity. beta-phenylalanine eukaryotic elongation factor 2 kinase Homo sapiens