Title : Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions.

Pub. Date : 2018 May

PMID : 29193038






2 Functional Relationships(s)
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Protein Name
Organism
1 OCT1 mediates metformin distribution to the liver (key biophase). Metformin solute carrier family 22 member 1 Homo sapiens
2 As OCT1 modulation impacts metformin response, but not pharmacokinetics (PK), metformin DDI studies require pharmacodynamic endpoint(s) to inform rational metformin dose adjustment. Metformin solute carrier family 22 member 1 Homo sapiens