Pub. Date : 2017 Oct 24
PMID : 29179438
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Valproate hampers podocyte acquisition of immune phenotypes via intercepting the GSK3beta facilitated NFkB activation. | Valproic Acid | glycogen synthase kinase 3 beta | Mus musculus |
| 2 | In contrast, valproate, an anticonvulsant and mood stabilizer, offset GSK3beta overactivity in LPS-injured podocytes and mitigated NFkB activation and podocyte acquisition of immune phenotypes as well as the ensuing cytopathic changes, podocyte cytoskeleton disorganization and dysfunction. | Valproic Acid | glycogen synthase kinase 3 beta | Mus musculus |
| 3 | The protective effect of valproate was strikingly blunted in podocytes expressing the constitutively active GSK3beta, suggesting an essential role of inhibitory phosphorylation of GSK3beta. | Valproic Acid | glycogen synthase kinase 3 beta | Mus musculus |
| 4 | The protective effect of valproate was strikingly blunted in podocytes expressing the constitutively active GSK3beta, suggesting an essential role of inhibitory phosphorylation of GSK3beta. | Valproic Acid | glycogen synthase kinase 3 beta | Mus musculus |
| 5 | In vivo in LPS-injured mice, valproate therapy abolished GSK3beta overactivity in glomeruli and attenuated podocyte injury and albuminuria, concomitant with a lessened NFkB activation and diminished induction of diverse podocytopathic immune molecules in podocytes and glomeruli. | Valproic Acid | glycogen synthase kinase 3 beta | Mus musculus |
| 6 | Taken together, valproate directly protects against podocyte injury and hampers podocyte acquisition of de novo immune phenotypes via intercepting the GSK3beta facilitated NFkB activation. | Valproic Acid | glycogen synthase kinase 3 beta | Mus musculus |