Pub. Date : 2018 Jan
PMID : 29177954
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pharmacogenetic study of the impact of ABCB1 single-nucleotide polymorphisms on lenalidomide treatment outcomes in patients with multiple myeloma: results from a phase IV observational study and subsequent phase II clinical trial. | Lenalidomide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Lenalidomide (Len) is excreted mainly via the kidneys, and, given the expression of P-gp in the renal tubuli, single-nucleotide polymorphisms (SNPs) in the ABCB1 gene may influence Len plasma concentrations and, subsequently, the outcome of treatment. | Lenalidomide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Lenalidomide (Len) is excreted mainly via the kidneys, and, given the expression of P-gp in the renal tubuli, single-nucleotide polymorphisms (SNPs) in the ABCB1 gene may influence Len plasma concentrations and, subsequently, the outcome of treatment. | Lenalidomide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSIONS: Our findings show a limited influence of ABCB1 genotype on lenalidomide treatment efficacy and safety. | Lenalidomide | ATP binding cassette subfamily B member 1 | Homo sapiens |