Title : Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

Pub. Date : 2018 Jan 1

PMID : 29170024






1 Functional Relationships(s)
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Protein Name
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1 The BET family consists of four isoforms (BRD2, BRD3, BRD4, and BRDT/BRDT6) which are distinguished by the presence of two tandem bromodomains (BD1 and BD2) that independently recognize acetylated-lysine (KAc) residues and appear to have distinct biological roles. 4-Quinolinecarbamic acid, 2-butoxy-, 2-(diethylamino)ethyl ester defensin beta 1 Homo sapiens