Title : Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors.

Pub. Date : 2018 Apr

PMID : 29155491






1 Functional Relationships(s)
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1 Ketoconazole effectively inhibited CLZ metabolism in five of seven livers that catalysed CYP3A4-dependent testosterone 6beta-hydroxylation at or above the median rate and in four other livers with lower intrinsic CYP3A4 activity. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens