Title : Mutagenesis of Sequence Determinants of Truncated Porcine ALOX15 Induces Changes in the Reaction Specificity by Altering the Catalytic Mechanism of Initial Hydrogen Abstraction.

Pub. Date : 2018 Jan 19

PMID : 29154477






1 Functional Relationships(s)
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1 Among mammalian ALOX15 orthologs there are arachidonic acid 12- and 15-lipoxygenating enzymes and recent studies suggested an evolutionary switch in that reaction specificity during late primate development. Arachidonic Acid arachidonate 15-lipoxygenase Homo sapiens