Title : Structure-Based Design and Synthesis of New Estrane-Pyridine Derivatives as Cytochrome P450 (CYP) 1B1 Inhibitors.

Pub. Date : 2017 Nov 9

PMID : 29152048






1 Functional Relationships(s)
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1 The position of the nitrogen atom in the aromatic ring has little influence on their inhibition potency, but compounds with a pyridinyl at C2 of the steroid nucleus are more potent CYP1B1 inhibitors than those with a pyridinyl at C3 or C4. Steroids cytochrome P450 family 1 subfamily B member 1 Homo sapiens