Title : A critical role of TRPM2 channel in Aβ42 -induced microglial activation and generation of tumor necrosis factor-α.

Pub. Date : 2018 Mar

PMID : 29143372






1 Functional Relationships(s)
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1 Collectively, our results suggest that PKC/NOX-mediated generation of ROS and subsequent activation of PARP-1 play a role in Abeta42 -induced TRPM2 channel activation and TRPM2-dependent activation of the PYK2/MEK/ERK signalling pathway acts as a positive feedback to further facilitate activation of PARP-1 and TRPM2 channel. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens