Pub. Date : 2017 Dec
PMID : 29135906
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. | Cyclosporine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | The aim of this study was to assess the impact of age, CYP3A5*3, CYP3A4*22, and POR*28 alleles on CsA pharmacokinetics in pediatric renal transplant recipients. | Cyclosporine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | Carriers of CYP3A5*3 allele aged <=6 years required higher dose of CsA and achieved lower C0/dose and C2/dose, at most time points, than older carriers of this allele. | Cyclosporine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 4 | CONCLUSIONS: Younger age, POR*28 allele, and CYP3A5*3 allele were associated with higher CsA dosing requirements and lower concentration/dose ratio. | Cyclosporine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |