Title : Upregulation of PRMT6 by LPS suppresses Klotho expression through interaction with NF-κB in glomerular mesangial cells.

Pub. Date : 2018 Apr

PMID : 29131380






3 Functional Relationships(s)
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1 NF-kappaB was identified as a substrate for arginine methylation and interacted with PRMT6 in MES-13 cells. 2-(N-morpholino)ethanesulfonic acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Inhibition of PRMT activity by AMI-1 blocked LPS-induced NF-kappaB nuclear translocation in MES-13 cells. 2-(N-morpholino)ethanesulfonic acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 Our data indicate that NF-kappaB negatively regulated Klotho expression with an interaction with PRMT6, which was upregulated by LPS in MES-13 cells. 2-(N-morpholino)ethanesulfonic acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus