Title : New insights of subfertility among transplanted women: Immunosuppressive drug FK506 leads to calcium leak and oocyte activation before fertilization.

Pub. Date : 2018 Mar

PMID : 29131377






1 Functional Relationships(s)
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1 QPCR demonstrated that Fbxo43 and P27kip, which are related to the release of MII oocyte arrest, and calcium channel partner protein Orai1 were downregulated, while Cdc2 and Ca2+ sensor at ER, stromal interaction molecule 1 (Stim1) were upregulated for a short time after adding FK506. Tacrolimus ORAI calcium release-activated calcium modulator 1 Homo sapiens