Title : Effects of ketoconazole on cyclophosphamide metabolism: evaluation of CYP3A4 inhibition effect using the in vitro and in vivo models.

Pub. Date : 2018 Feb 9

PMID : 29129847






1 Functional Relationships(s)
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Protein Name
Organism
1 N-dechloroethylation of CP mediated by the enzyme CYP3A4 yields nephrotoxic and neurotoxic chloroacetaldehyde (CAA) in equimolar amount to DECP. Nitrogen cytochrome P450 family 3 subfamily A member 4 Homo sapiens