Title : Budesonide facilitates weaning from mechanical ventilation in difficult-to-wean very severe COPD patients: Association with inflammatory mediators and cells.

Pub. Date : 2018 Apr

PMID : 29127842






2 Functional Relationships(s)
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1 Dynamic compliance was significantly improved in the budesonide group on days 3 (p=0.018) and 5 (p=0.011) The levels of CXCL-8 and IL-6 diminished on days 3-5 after start of budesonide (p<0.05). Budesonide C-X-C motif chemokine ligand 8 Homo sapiens
2 CONCLUSION: In COPD patients on MV, nebulized budesonide was associated with reduced BAL CXCL8 and IL-6 levels and neutrophil numbers as well as an improvement in ventilatory mechanics and facilitated weaning. Budesonide C-X-C motif chemokine ligand 8 Homo sapiens