Title : A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer.

Pub. Date : 2017 Nov 9

PMID : 29123088






6 Functional Relationships(s)
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Protein Name
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1 A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer. Paclitaxel nucleolin Homo sapiens
2 Here we design and synthesize a highly water-soluble nucleolin aptamer-paclitaxel conjugate (NucA-PTX) that selectively delivers PTX to the tumor site. Paclitaxel nucleolin Homo sapiens
3 Here we design and synthesize a highly water-soluble nucleolin aptamer-paclitaxel conjugate (NucA-PTX) that selectively delivers PTX to the tumor site. Paclitaxel nucleolin Homo sapiens
4 Here we design and synthesize a highly water-soluble nucleolin aptamer-paclitaxel conjugate (NucA-PTX) that selectively delivers PTX to the tumor site. Paclitaxel nucleolin Homo sapiens
5 By connecting a tumor-targeting nucleolin aptamer (NucA) to the active hydroxyl group at 2" position of PTX via a cathepsin B sensitive dipeptide bond, NucA-PTX remains stable and inactive in the circulation. Paclitaxel nucleolin Homo sapiens
6 By connecting a tumor-targeting nucleolin aptamer (NucA) to the active hydroxyl group at 2" position of PTX via a cathepsin B sensitive dipeptide bond, NucA-PTX remains stable and inactive in the circulation. Paclitaxel nucleolin Homo sapiens