Pub. Date : 2018 Jan 1
PMID : 29122594
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol efflux. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Inhibition of the NLRP3 inflammasome attenuated foam cell formation, diminished ox-LDL uptake, and promoted cholesterol efflux from THP-1 macrophages. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Collectively, our findings show that inhibition of the NLRP3 inflammasome decreases foam cell formation of THP-1 macrophages via suppression of ox-LDL uptake and enhancement of cholesterol efflux, which may be due to downregulation of CD36 expression and upregulation of ABCA1 and SR-BI expression, respectively. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |