Title : Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein.

Pub. Date : 2017

PMID : 29121121






1 Functional Relationships(s)
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1 Importantly, rhodamine 123 could increase the Kintrinsic (Ki) value of emodin linearly, whereas, verapamil could not, implying that emodin competitively bound to the R site of P-gp and noncompetition existed between emodin and verapamil at the M site, in a good accordance with the results of molecular docking that emodin bound to the R site of P-gp with higher affinity. Verapamil ATP binding cassette subfamily B member 1 Homo sapiens