Title : Quetiapine prevents Aβ25-35-induced cell death in cultured neuron by enhancing brain-derived neurotrophic factor release from astrocyte.

Pub. Date : 2018 Jan 17

PMID : 29120942






3 Functional Relationships(s)
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1 Quetiapine prevents Abeta25-35-induced cell death in cultured neuron by enhancing brain-derived neurotrophic factor release from astrocyte. Quetiapine Fumarate brain derived neurotrophic factor Homo sapiens
2 Furthermore, we revealed that QTP increased both the release of brain-derived neurotrophic factor from cultured astrocytes and the phosphorylation of extracellular signal-regulated kinase after 24 h of treatment, which might be responsible for its protective effects on neurons. Quetiapine Fumarate brain derived neurotrophic factor Homo sapiens
3 In conclusion, our data demonstrated that QTP exerted its neuroprotective effects against amyloid toxicity by enhancing the brain-derived neurotrophic factor release from astrocytes. Quetiapine Fumarate brain derived neurotrophic factor Homo sapiens