Title : Correlation Between Steroid-Induced Osteonecrosis of The Femoral Head and Hepatic CYP3A Activity: A Systematic Review and Meta-Analysis.

Pub. Date : 2019 Mar

PMID : 29120670






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1 Correlation Between Steroid-Induced Osteonecrosis of The Femoral Head and Hepatic CYP3A Activity: A Systematic Review and Meta-Analysis. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 This study aims to review the investigations on the hepatic CYP3A (cytochrome P4503A enzyme) genetic polymorphisms in steroid-induced ONFH patients. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 This study aims to review the investigations on the hepatic CYP3A (cytochrome P4503A enzyme) genetic polymorphisms in steroid-induced ONFH patients. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens
4 The odds ratios, standard mean difference, and 95% confidence intervals were calculated to assess the effect of hepatic CYP3A activity on the rabbit model with steroid-induced ONFH. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens
5 RESULTS: High hepatic CYP3A activity significantly decreased the risk for steroid-induced ONFH in the rabbit model (p <. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens
6 The CYP3A gene may be potentially associated with increased risk of steroid-induced ONFH in the human allele model. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens
7 CONCLUSION: The study suggests that high hepatic CYP3A activity decreases the risk of steroid-induced ONFH. Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens