Title : Isolariciresinol-9'-O-α-L-arabinofuranoside protects against hydrogen peroxide‑induced apoptosis of human umbilical vein endothelial cells via a PI3K/Akt/Bad‑dependent pathway.

Pub. Date : 2018 Jan

PMID : 29115459






3 Functional Relationships(s)
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1 Isolariciresinol-9"-O-alpha-L-arabinofuranoside protects against hydrogen peroxide-induced apoptosis of human umbilical vein endothelial cells via a PI3K/Akt/Bad-dependent pathway. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens
2 Furthermore, the protein expression of phosphatidylinositol 3-kinase (PI3K), phosphorylated-Akt and Bcl-2-associated agonist of cell death (Bad) were increased, and reduced caspase-3 activation was observed, following treatment with MWS-19 in H2O2-treated HUVECs. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens
3 In conclusion, the results of the present study indicate that MWS-19 may protect against H2O2-induced HUVEC apoptosis via the PI3K/Akt/Bad signaling pathway. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens