Pub. Date : 2018 Jan
PMID : 29111377
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function. | polyglutamine | ataxin 3 | Homo sapiens |
| 2 | In the neurodegenerative disease spinocerebellar ataxia type 3 (SCA3), ataxin-3 contains an expanded polyglutamine (polyQ) stretch that leads to aggregation of the protein and neuronal dysfunction. | polyglutamine | ataxin 3 | Homo sapiens |
| 3 | In the neurodegenerative disease spinocerebellar ataxia type 3 (SCA3), ataxin-3 contains an expanded polyglutamine (polyQ) stretch that leads to aggregation of the protein and neuronal dysfunction. | polyglutamine | ataxin 3 | Homo sapiens |
| 4 | In the neurodegenerative disease spinocerebellar ataxia type 3 (SCA3), ataxin-3 contains an expanded polyglutamine (polyQ) stretch that leads to aggregation of the protein and neuronal dysfunction. | polyglutamine | ataxin 3 | Homo sapiens |
| 5 | In the neurodegenerative disease spinocerebellar ataxia type 3 (SCA3), ataxin-3 contains an expanded polyglutamine (polyQ) stretch that leads to aggregation of the protein and neuronal dysfunction. | polyglutamine | ataxin 3 | Homo sapiens |
| 6 | Hence, we analyzed the repertoire of proteins interacting with normal and polyQ expanded ataxin-3 by mass spectrometry. | polyglutamine | ataxin 3 | Homo sapiens |
| 7 | This showed that both normal and polyQ expanded ataxin-3 interacted with components of the protein quality control system and mitochondria. | polyglutamine | ataxin 3 | Homo sapiens |
| 8 | Five proteins showed increased interaction with polyQ expanded ataxin-3 relative to normal and three of these were mitochondrial proteins. | polyglutamine | ataxin 3 | Homo sapiens |