Title : Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease.

Pub. Date : 2017 Nov 16

PMID : 29105594






1 Functional Relationships(s)
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1 BACKGROUND: In a previous trial involving patients with early autosomal dominant polycystic kidney disease (ADPKD; estimated creatinine clearance, >=60 ml per minute), the vasopressin V2-receptor antagonist tolvaptan slowed the growth in total kidney volume and the decline in the estimated glomerular filtration rate (GFR) but also caused more elevations in aminotransferase and bilirubin levels. Tolvaptan arginine vasopressin receptor 2 Homo sapiens