Title : Variations in catechol O-methyltransferase activity in rodent tissues: possible role in estrogen carcinogenicity.

Pub. Date : 1989 Jan

PMID : 2910532






1 Functional Relationships(s)
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1 The significantly lower COMT activity in the hamster liver and red blood cells suggests that under chronic estrogen treatment at high doses, the concentration of catechol estrogens in these tissues may exceed the capacity of COMT to effectively catalyse their O-methylation into inactive metabolites. catechol catechol-O-methyltransferase Mus musculus