Title : A Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug-Drug Interactions of Buprenorphine After Subcutaneous Administration of CAM2038 With Perpetrators of CYP3A4.

Pub. Date : 2018 Mar

PMID : 29102550






1 Functional Relationships(s)
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1 The strong CYP3A4 inhibitor ketoconazole was predicted to increase the buprenorphine exposure by 35% for the Q1W formulation and 34% for Q4W formulation, respectively. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens