Title : Development of Guanfacine Extended-Release Dosing Strategies in Children and Adolescents with ADHD Using a Physiologically Based Pharmacokinetic Model to Predict Drug-Drug Interactions with Moderate CYP3A4 Inhibitors or Inducers.

Pub. Date : 2018 Apr

PMID : 29098603






1 Functional Relationships(s)
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1 The model was validated using clinical PK data for co-administration of GXR with ketoconazole (strong CYP3A4 inhibitor) or rifampicin (strong CYP3A4 inducer). Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens