Title : Oxidative stress-elicited autophagosome accumulation contributes to human neuroblastoma SH-SY5Y cell death induced by PBDE-47.

Pub. Date : 2017 Dec

PMID : 29096325






3 Functional Relationships(s)
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1 Results showed PBDE-47 could increase autophagic level (performation of cell ultrastructure with double membrane formation, MDC-positive cells raised, autophagy-related proteins LC3-II, Beclin1 and P62 increased) after cells exposed to PBDE-47. pentabromodiphenyl ether nucleoporin 62 Homo sapiens
2 Then cells were exposed to PBDE-47 (1, 5, 10mumol/L) respectively for 1, 3, 6, 9, 12, 18, 24h, and the results showed that PBDE-47 increased the levels of LC3-II, Beclin1 and P62 in 5, 10mumol/L (9, 12, 18, 24h) PBDE-47 exposed groups. pentabromodiphenyl ether nucleoporin 62 Homo sapiens
3 Then cells were exposed to PBDE-47 (1, 5, 10mumol/L) respectively for 1, 3, 6, 9, 12, 18, 24h, and the results showed that PBDE-47 increased the levels of LC3-II, Beclin1 and P62 in 5, 10mumol/L (9, 12, 18, 24h) PBDE-47 exposed groups. pentabromodiphenyl ether nucleoporin 62 Homo sapiens