Title : Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells.

Pub. Date : 2017

PMID : 29093337






3 Functional Relationships(s)
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1 Among these bisphenols, BPAF up-regulated the expression of ERbeta, and this was coupled with the abrogation of estrogen response element (ERE)-mediated transcriptional activities as well as the down-regulation of Cdc2 expression in MCF-7 cells, without influencing the expression of ERalpha. 4,4'-hexafluorisopropylidene diphenol estrogen receptor 1 Homo sapiens
2 BPAF functioned as an agonist of ERalpha at lower concentrations (nanomolar order), but did not exhibit any modulatory action on ERalpha transiently expressed in SK-BR-3 cells in the presence or absence of 17beta-estradiol (E2) at higher concentrations (micromolar order). 4,4'-hexafluorisopropylidene diphenol estrogen receptor 1 Homo sapiens
3 Since ERbeta is a suppressive molecule of ERalpha function, these results provide rational evidence for BPAF functioning as an anti-estrogenic compound via the induction of ERbeta at higher concentrations. 4,4'-hexafluorisopropylidene diphenol estrogen receptor 1 Homo sapiens