Title : Inhibition of c-Jun N-Terminal Kinase Protects Against Brain Damage and Improves Learning and Memory After Traumatic Brain Injury in Adult Mice.

Pub. Date : 2018 Aug 1

PMID : 29088310






1 Functional Relationships(s)
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1 Treating 2 different models of TBI mice with SP600125 for 7 days dramatically inhibited activated JNK, resulting in marked reductions of amyloid precursor protein (APP) expression level and in amyloid beta production and hyperphosphorylated tau and regulation of the abnormal expression of secretases. pyrazolanthrone amyloid beta (A4) precursor protein Mus musculus