Title : Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.

Pub. Date : 2018 Jan 15

PMID : 29084919






1 Functional Relationships(s)
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1 Moreover, we demonstrated that hypoxia activated proline biosynthesis via upregulation of ALDH18A1, subsequently leading to accumulation of hydroxyproline via attenuated PRODH2 activity. Proline aldehyde dehydrogenase 18 family member A1 Homo sapiens