Title : 3D-QSAR, molecular docking, and ONIOM studies on the structure-activity relationships and action mechanism of nitrogen-containing bisphosphonates.

Pub. Date : 2018 Mar

PMID : 29080272






2 Functional Relationships(s)
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1 Nitrogen-containing bisphosphonates (N-BPs) have been used widely to treat various bone diseases by inhibiting the key enzyme farnesyl pyrophosphate synthase (FPPS) in the mevalonate pathway. Diphosphonates farnesyl diphosphate synthase Homo sapiens
2 Nitrogen-containing bisphosphonates (N-BPs) have been used widely to treat various bone diseases by inhibiting the key enzyme farnesyl pyrophosphate synthase (FPPS) in the mevalonate pathway. Diphosphonates farnesyl diphosphate synthase Homo sapiens