Title : Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts.

Pub. Date : 2018 Mar

PMID : 29079702






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Moreover, MT prevented tert-butyl hydroperoxide (tBHP)-reduced insulin-stimulated Akt2 phosphorylation in MT-TG cardiomyocytes, which was abolished by specific silencing of Akt2. tert-Butylhydroperoxide thymoma viral proto-oncogene 2 Mus musculus
2 Moreover, MT prevented tert-butyl hydroperoxide (tBHP)-reduced insulin-stimulated Akt2 phosphorylation in MT-TG cardiomyocytes, which was abolished by specific silencing of Akt2. tert-Butylhydroperoxide thymoma viral proto-oncogene 2 Mus musculus
3 Moreover, MT prevented tert-butyl hydroperoxide (tBHP)-reduced insulin-stimulated Akt2 phosphorylation in MT-TG cardiomyocytes, which was abolished by specific silencing of Akt2. tert-Butylhydroperoxide thymoma viral proto-oncogene 2 Mus musculus
4 Moreover, MT prevented tert-butyl hydroperoxide (tBHP)-reduced insulin-stimulated Akt2 phosphorylation in MT-TG cardiomyocytes, which was abolished by specific silencing of Akt2. tert-Butylhydroperoxide thymoma viral proto-oncogene 2 Mus musculus
5 Specific silencing of TRB3 blocked tBHP inhibition of insulin-stimulated Akt2 phosphorylation in WT cardiomyocytes, whereas overexpression of TRB3 in MT-TG cardiomyocytes and hearts abolished MT preservation of insulin-stimulated Akt2 signals and MT prevention of DCM. tert-Butylhydroperoxide thymoma viral proto-oncogene 2 Mus musculus