Title : Do CYP2C19 and ABCB1 gene polymorphisms and low CYP3A4 isoenzyme activity have an impact on stent implantation complications in acute coronary syndrome patients?

Pub. Date : 2017

PMID : 29075133






2 Functional Relationships(s)
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1 CYP3A4 isoenzyme activity was determined by urine cortisol and 6-beta-hydroxycortisol levels. Hydrocortisone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 RESULTS: Low mean 6-beta-hydroxycortisol/cortisol ratio is indicative of impaired CYP3A4 activity and was associated with higher risk of thrombosis (b coefficient=0.022, SE 0.009, p=0.021 in the linear regression model). Hydrocortisone cytochrome P450 family 3 subfamily A member 4 Homo sapiens