Pub. Date : 2017 Oct
PMID : 29070145
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effect of ERK1/2 Signaling Pathway Inhibitor PD98059 on the Expression of Ras, BRaf, MEK, ERK1/2 in Marrow Nucleated Red Blood Cells of CMS Patients]. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | [Effect of ERK1/2 Signaling Pathway Inhibitor PD98059 on the Expression of Ras, BRaf, MEK, ERK1/2 in Marrow Nucleated Red Blood Cells of CMS Patients]. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | OBJECTIVE: To investigate the effect of ERK1 / 2 signaling pathway inhibitor PD98059 on Ras, Raf, MEK, ERK1, ERK2 expression in order to explore a new way for basic research and clinical treatment of the chronic mountain sickness(CMS). | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | OBJECTIVE: To investigate the effect of ERK1 / 2 signaling pathway inhibitor PD98059 on Ras, Raf, MEK, ERK1, ERK2 expression in order to explore a new way for basic research and clinical treatment of the chronic mountain sickness(CMS). | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Homo sapiens |
| 5 | Compared with the PD98059 20 mol/L group, the expression level of ERK1/2 mRNA was statistically significant (P=0.001, 0.002). | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Homo sapiens |
| 6 | Compared with the PD98059 20 mol/L group, the difference of p-ERK1/2 protein level in other 4 groups were statistically significant (P values were <0.001, 0.007). | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Homo sapiens |
| 7 | CONCLUSION: PD98059 can up-regulate the expressions of ERK1/2 miRNA and p-ERK1/2 protein in bone marrow nucleated red blood cells, the Ras / Raf / MEK / ERK 1/2 pathway is the main signal transduction pathway in regulating bone marrow nucleated red blood cells, suggesting that Ras/Raf /MEK /ERK 1/2 pathway may be involved in the pathogenesis of chronic mountain sickness process. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Homo sapiens |
| 8 | CONCLUSION: PD98059 can up-regulate the expressions of ERK1/2 miRNA and p-ERK1/2 protein in bone marrow nucleated red blood cells, the Ras / Raf / MEK / ERK 1/2 pathway is the main signal transduction pathway in regulating bone marrow nucleated red blood cells, suggesting that Ras/Raf /MEK /ERK 1/2 pathway may be involved in the pathogenesis of chronic mountain sickness process. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Homo sapiens |
| 9 | CONCLUSION: PD98059 can up-regulate the expressions of ERK1/2 miRNA and p-ERK1/2 protein in bone marrow nucleated red blood cells, the Ras / Raf / MEK / ERK 1/2 pathway is the main signal transduction pathway in regulating bone marrow nucleated red blood cells, suggesting that Ras/Raf /MEK /ERK 1/2 pathway may be involved in the pathogenesis of chronic mountain sickness process. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Homo sapiens |
| 10 | CONCLUSION: PD98059 can up-regulate the expressions of ERK1/2 miRNA and p-ERK1/2 protein in bone marrow nucleated red blood cells, the Ras / Raf / MEK / ERK 1/2 pathway is the main signal transduction pathway in regulating bone marrow nucleated red blood cells, suggesting that Ras/Raf /MEK /ERK 1/2 pathway may be involved in the pathogenesis of chronic mountain sickness process. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Homo sapiens |