Pub. Date : 2019 Oct
PMID : 29064206
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Correlation of changes in HIF-1alpha and p53 expressions with vitamin B3 deficiency in skin cancer patients. | Niacinamide | tumor protein p53 | Homo sapiens |
| 2 | BACKGROUND: To investigate the correlation of changes in hypoxia-inducible factor-1alpha (HIF-1alpha) and p53 expressions with vitamin B3 deficiency in skin cancer patients. | Niacinamide | tumor protein p53 | Homo sapiens |
| 3 | The protein and mRNA expression levels of HIF-1alpha and p53 in tissues of skin cancer patients were significantly decreased at 1 week after the oral administration of vitamin B3 compared with those before the oral administration of vitamin B3 (P<0.05), but the protein and mRNA expression levels of HIF-1alpha and p53 in tissues of skin cancer patients in placebo group had no significant changes (P>0.05). | Niacinamide | tumor protein p53 | Homo sapiens |
| 4 | The protein and mRNA expression levels of HIF-1alpha and p53 in tissues of skin cancer patients were significantly decreased at 1 week after the oral administration of vitamin B3 compared with those before the oral administration of vitamin B3 (P<0.05), but the protein and mRNA expression levels of HIF-1alpha and p53 in tissues of skin cancer patients in placebo group had no significant changes (P>0.05). | Niacinamide | tumor protein p53 | Homo sapiens |
| 5 | The protein and mRNA expression levels of HIF-1alpha and p53 in tissues of skin cancer patients were significantly decreased at 1 week after the oral administration of vitamin B3 compared with those before the oral administration of vitamin B3 (P<0.05), but the protein and mRNA expression levels of HIF-1alpha and p53 in tissues of skin cancer patients in placebo group had no significant changes (P>0.05). | Niacinamide | tumor protein p53 | Homo sapiens |
| 6 | The vitamin B3 deficiency in skin cancer patients was positively correlated with the expressions of HIF-1alpha and p53. | Niacinamide | tumor protein p53 | Homo sapiens |
| 7 | CONCLUSIONS: The expression levels of HIF-1alpha and p53 in tissues of skin cancer patients are significantly increased compared with those in skin tissues of healthy people, and the changes in their expressions are positively correlated with the vitamin B3 deficiency. | Niacinamide | tumor protein p53 | Homo sapiens |