Title : 6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis.

Pub. Date : 2017 Oct 12

PMID : 29057044






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 It demonstrates excellent efficacy against TB but induces phospholipidosis at high doses, has a long terminal elimination half-life (due to its high lipophilicity), and exhibits potent hERG channel inhibition, resulting in clinical QTc interval prolongation. Terbium ETS transcription factor ERG Homo sapiens