Pub. Date : 2017
PMID : 29045950
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Ppargamma/Lxralpha Signaling Pathway-Dependent Manner. | leonurine | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |
| 2 | Besides, both the mRNA and protein levels of ABCA1/G1, PPARgamma and LXRalpha were enhanced by leonurine, which were attenuated by LXRalpha siRNA or PPARgamma siRNA transfection. | leonurine | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |
| 3 | Besides, both the mRNA and protein levels of ABCA1/G1, PPARgamma and LXRalpha were enhanced by leonurine, which were attenuated by LXRalpha siRNA or PPARgamma siRNA transfection. | leonurine | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |
| 4 | CONCLUSIONS: Leonurine can promote cholesterol efflux and alleviate cellular lipid accumulation by magnifying the expression of ABCA1/G1 in a PPARgamma/LXRalpha signaling pathway-dependent manner in human THP-1 macrophage-derived foam cells and abate atherogenesis in apoE-/- mice, which may offer a promising therapeutic intervention of leonurine in protecting against AS. | leonurine | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |