Pub. Date : 2017 Aug 1
PMID : 29044428
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the mouse, retinoic acid induces ovarian Stra8 expression and entry of germ cells into meiosis. | Tretinoin | stimulated by retinoic acid gene 8 | Mus musculus |
| 2 | In developing mouse testes, cytochrome P450 family 26, subfamily b, polypeptide 1 (CYP26B1) produced by the Sertoli cells degrades retinoic acid, preventing Stimulated by Retinoic Acid Gene 8 (Stra8), expression and inhibiting meiosis. | Tretinoin | stimulated by retinoic acid gene 8 | Mus musculus |
| 3 | In developing mouse testes, cytochrome P450 family 26, subfamily b, polypeptide 1 (CYP26B1) produced by the Sertoli cells degrades retinoic acid, preventing Stimulated by Retinoic Acid Gene 8 (Stra8), expression and inhibiting meiosis. | Tretinoin | stimulated by retinoic acid gene 8 | Mus musculus |
| 4 | We therefore examined aspects of the retinoic acid/STRA8/CYP26B1 pathway during gonadal development in the tammar wallaby, a marsupial, to understand whether retinoic acid stimulation of STRA8 and CYP26B1 degradation of retinoic acid was conserved between widely divergent mammals. | Tretinoin | stimulated by retinoic acid gene 8 | Mus musculus |
| 5 | We therefore examined aspects of the retinoic acid/STRA8/CYP26B1 pathway during gonadal development in the tammar wallaby, a marsupial, to understand whether retinoic acid stimulation of STRA8 and CYP26B1 degradation of retinoic acid was conserved between widely divergent mammals. | Tretinoin | stimulated by retinoic acid gene 8 | Mus musculus |
| 6 | Exposure of pre-meiotic tammar ovaries to exogenous retinoic acid in vitro upregulated STRA8 expression compared to controls. | Tretinoin | stimulated by retinoic acid gene 8 | Mus musculus |